Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539208 | 0.86 | POLB (0.44) | MAPTMRGPRX4NOTUMPTGDR2POLB | |
| SCHEMBL4541733 | 0.84 | CFTR (0.43) | CFTRMAPTLMNATSHRKMT2A | |
| SCHEMBL4542173 | 0.81 | CFTR (0.40) | CFTRMAPTLMNAMRGPRX4TSHR | |
| SCHEMBL4539907 | 0.78 | CFTR (0.38) | CFTRMAPTLMNAMRGPRX4TSHR | |
| SCHEMBL4541949 | 0.76 | MAPK14 (0.48) | MAPTLMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL4542227 | 0.75 | ALDH1A1 (0.41) | MAPTLMNATSHRKMT2AMEN1 | |
| SCHEMBL4544013 | 0.74 | LDHA (0.40) | CFTRMAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL4541068 | 0.74 | LOXL2 (0.42) | CFTRMAPTLMNAMRGPRX4SMN1; SMN2 | |
| SCHEMBL25085889 | 0.73 | CFTR (0.65) | CFTRMAPTLMNAMRGPRX4CETP | |
| SCHEMBL4542130 | 0.71 | LMNA (0.40) | MAPTLMNAMRGPRX4KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |