Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 13/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984977 | 0.85 | NOTUM (0.43) | GAAKDM4ENOTUMKEAP1CYP19A1 | |
| SCHEMBL6428993 | 0.82 | NOTUM (0.44) | GAAKDM4ENOTUMKEAP1MEN1 | |
| SCHEMBL21376045 | 0.78 | NOTUM (0.49) | GAANOTUMKEAP1CYP19A1KMT2A | |
| SCHEMBL18284747 | 0.78 | NOTUM (0.46) | NOTUMKEAP1CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL18284817 | 0.77 | NOTUM (0.43) | NOTUMKEAP1CYP19A1CYP1A2CYP2C9 | |
| SCHEMBL28978245 | 0.77 | NOTUM (0.43) | GAAKDM4ENOTUMKEAP1MEN1 | |
| SCHEMBL30288919 | 0.77 | NOTUM (0.43) | GAAKDM4ENOTUMKEAP1MEN1 | |
| SCHEMBL170100 | 0.76 | IDO1 (0.47) | GAAKDM4ENOTUMKEAP1HTT | |
| SCHEMBL20605667 | 0.76 | NOTUM (0.50) | NOTUMKEAP1CYP19A1MEN1KMT2A | |
| SCHEMBL241942 | 0.76 | NOTUM (0.50) | NOTUMKEAP1CYP1A2CYP2C9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180369262-A1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | TETARD, INC. | 2018-12-27 | — | — | US | disclosed |
| EP-2365747-B1 | METHODS FOR TREATING GASTROINTESTINAL DISEASES | CEMPRA PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2362727-B1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | CEMPRA PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9901592-B2 | Methods for treating resistant diseases using triazole containing macrolides | CEMPRA PHARMACEUTICALS, INC. (US) | 2018-02-27 | — | — | US | disclosed |
| US-9815863-B2 | Hydrogen bond forming fluoro ketolides for treating diseases | CEMPRA PHARMACEUTICALS, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-9669046-B2 | Biodefenses using triazole-containing macrolides | CEMPRA PHARMACEUTICALS, INC. (US) | 2017-06-06 | — | — | US | disclosed |
| CN-104093715-B | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives | 埃科特莱茵药品有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-103626742-B | Bi-aryl meta-pyrimidine inhibitors of kinases | 塔格根公司 | 2017-04-26 | — | — | CN | disclosed |
| US-9439918-B2 | Methods for treating gastrointestinal diseases | CEMPRA PHARMACEUTICALS, INC. (US) | 2016-09-13 | — | — | US | disclosed |
| EP-3031460-A1 | BIODEFENSES USING TRIAZOLE-CONTAINING MACROLIDES | Cempra Pharmaceuticals Inc. (US) | 2016-06-15 | — | — | EP | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |
| EP-1981876-A1 | TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | Arrow Therapeutics Limited (GB) | 2008-10-22 | — | — | EP | disclosed |
| CN-101137653-A | Thiazole-4-carboxamide derivatives as MGLUR5 antagonists | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | CN | disclosed |
| WO-2007080401-A1 | TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2007-07-19 | — | — | WO | disclosed |
| US-4463007-A | ANTIALLERGENS | BASF AKTIENGESELLSCHAFT (DE) | 1984-07-31 | — | — | US | disclosed |
| EP-0001774-A1 | Derivatives of BPTI (basic pancreatic trypsin-inhibitor), process for their preparation and their use as medicines | BAYER AG (DE) | 1979-05-16 | — | — | EP | disclosed |
| EP-0001773-A1 | Derivatives of BPTI (basic pancreatic trypsin-inhibitor), process for their preparation and their use as medicines | BAYER AG (DE) | 1979-05-16 | — | — | EP | disclosed |
| US-4153687-A | Derivatives, having an inhibitory action against protease and an antiphlogistic action, of the trypsin-kallikrein inhibitor obtained from cattle organs (BPTI), their preparation and their use as medicaments | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-08 | — | — | US | disclosed |
| US-4060531-A | OPTICAL BRIGTENERS | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1977-11-29 | — | — | US | disclosed |
| US-4020083-A | ANTIINFLAMMATORY | SANDOZ, INC. (US) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180369262-A1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | LIPA, PNLIP, LIPC | GAA 13/4885KDM4E 4245/4885NOTUM 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.