Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540243 | 1.00 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2518268 | 0.85 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2518271 | 0.85 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL4540245 | 0.76 | IDO1 (0.54) | LMNAHPGDHTT | |
| SCHEMBL4369896 | 0.75 | HIF1A (0.39) | ALDH1A1SMN1; SMN2RAB9ALMNAKMT2A | |
| SCHEMBL2519338 | 0.74 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTHPGDHTT | |
| SCHEMBL12230806 | 0.74 | LMNA (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2519337 | 0.74 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTHPGDHTT | |
| SCHEMBL4368291 | 0.72 | GRM4 (0.44) | — | |
| SCHEMBL4368296 | 0.72 | GRM4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879573-A4 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1879573-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122150-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2006-11-16 | — | — | WO | claimed |