Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450534 | 0.86 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL451864 | 0.84 | HPGD (0.52) | ALDH1A1KDM4ESMN1; SMN2GAAHTR7 | |
| SCHEMBL449318 | 0.83 | HTR7 (0.54) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL449257 | 0.83 | HTR7 (0.54) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL449587 | 0.81 | SMN1; SMN2 (0.60) | ALDH1A1KDM4ESMN1; SMN2GAAHTR7 | |
| SCHEMBL454261 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2GAAHTR7 | |
| SCHEMBL451951 | 0.77 | HTR7 (0.53) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL450438 | 0.76 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL449747 | 0.75 | HTR7 (0.55) | ALDH1A1KDM4ESMN1; SMN2HTR7MAPT | |
| SCHEMBL1554547 | 0.74 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2GAAHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120064025-A1 | Quinazolinone Modulators Of Nuclear Receptors | EXELIXIS, INC. (US) | 2012-03-15 | — | — | US | disclosed |
| EP-1521746-B1 | QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS | X CEPTOR THERAPEUTICS INC (US) | 2011-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064025-A1 | Quinazolinone Modulators Of Nuclear Receptors | NR1H4, NR1H2, NR1H3 | ALDH1A1 3161/4885KDM4E 3717/4885SMN1; SMN2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.