SCHEMBL4540441

SCHEMBL4540441

COc1ccc2c(N)c3ccc(Cl)cc3nc2c1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.58
KDM4E B2RXH2 2/20 0.58
ACHE P22303 3/20 0.57
MBNL1 Q9NR56 1/20 0.52
KMT2A Q03164 3/20 0.49
NR4A2 P43354 1/20 0.49
PHLPP2 Q6ZVD8 2/20 0.48
ADORA2A P29274 1/20 0.48
CYP19A1 P11511 1/20 0.48
BCHE P06276 2/20 0.48
CHRM1 P11229 1/20 0.48
EPHX2 P34913 1/20 0.48
MEN1 O00255 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
MYC P01106 1/20 0.46
NPC1 O15118 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
NQO2 P16083 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29445571 0.92 APP (0.70) APPKDM4EACHEMBNL1KMT2A
SCHEMBL106725 0.92 APP (0.70) APPKDM4EACHEMBNL1KMT2A
SCHEMBL12488031 0.92 APP (0.70) APPKDM4EACHEMBNL1KMT2A
SCHEMBL29365544 0.92 APP (0.70) APPKDM4EACHEMBNL1KMT2A
SCHEMBL11194565 0.87 KDM4E (0.61) KDM4EACHEMBNL1KMT2APHLPP2
Acridine SCHEMBL28132121 0.84 APP (0.60) APPKDM4EACHEMBNL1KMT2A
SCHEMBL15673323 0.82 APP (0.64) APPKDM4EACHEKMT2AADORA2A
SCHEMBL11442590 0.81 ALDH1A1 (0.69) KDM4EKMT2APHLPP2ADORA2ACYP19A1
SCHEMBL14126140 0.81 KDM4E (0.62) APPKDM4EMBNL1KMT2APHLPP2
SCHEMBL12068390 0.80 KDM4E (0.87) KDM4EMBNL1KMT2APHLPP2ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1948684-B1 PRODUCTION OF RECOMBINANT COLLAGEN LIKE PROTEINS AMSILK GMBH (DE) 2016-01-27 EP disclosed
US-20090162896-A1 Production of Recombinant Collagen Like Proteins AMSILK GMBH (DE) 2009-06-25 US disclosed
EP-1948684-A1 PRODUCTION OF RECOMBINANT COLLAGEN LIKE PROTEINS Technische Universität München (DE) 2008-07-30 EP disclosed
WO-2007057207-A1 PRODUCTION OF RECOMBINANT COLLAGEN LIKE PROTEINS TECHNISCHE UNIVERSITAET MUENCHEN (DE) 2007-05-24 WO disclosed
EP-1787995-A1 Recombinant mussel byssus protein Technische Universität München (DE) 2007-05-23 EP disclosed
US-4230601-A Calibrator composition based upon dialyzed blood serum EASTMAN KODAK COMPANY (US) 1980-10-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090162896-A1 Production of Recombinant Collagen Like Proteins COL14A1, YIPF5, COL2A1 APP 380/4885KDM4E 2006/4885ACHE 4190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.