Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813124 | 0.82 | NR1H2 (0.47) | — | |
| SCHEMBL4541570 | 0.81 | IKBKB (0.48) | PTGS2PTGS1 | |
| SCHEMBL25560260 | 0.80 | ALDH1A1 (0.49) | — | |
| SCHEMBL21163901 | 0.77 | KMT2A (0.48) | — | |
| SCHEMBL22529466 | 0.77 | PDK1 (0.49) | — | |
| SCHEMBL12813116 | 0.77 | MAPK14 (0.42) | PTGS2PTGS1MAPK14 | |
| SCHEMBL16585820 | 0.77 | PDK1 (0.40) | — | |
| SCHEMBL2348873 | 0.76 | KDM4E (0.52) | — | |
| SCHEMBL23093261 | 0.75 | PTGS2 (0.47) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL22097644 | 0.75 | PDK1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |