Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 13/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8040416 | 0.92 | PPARG (0.58) | MEN1KMT2APKMPPARG | |
| SCHEMBL8034344 | 0.90 | PPARG (0.54) | MEN1KMT2APPARGMAPTHDAC1 | |
| SCHEMBL4537762 | 0.89 | PPARG (0.48) | PPARGMAPTLMNAHDAC1HDAC8 | |
| SCHEMBL8034539 | 0.86 | PPARG (0.56) | PPARGHDAC1HDAC8HDAC6 | |
| SCHEMBL4538730 | 0.86 | PPARG (0.57) | PPARGMAPTSMN1; SMN2HDAC1HDAC3 | |
| SCHEMBL4537211 | 0.85 | KCNK3 (0.50) | PPARGMAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL4534800 | 0.85 | KMT2A (0.67) | MEN1KMT2APKMMAPT | |
| SCHEMBL8032490 | 0.84 | PPARG (0.55) | PPARGHDAC1HDAC3 | |
| SCHEMBL8038553 | 0.84 | PPARG (0.60) | PPARGHDAC1HDAC3HDAC2NCOR2 | |
| SCHEMBL8038556 | 0.83 | PPARG (0.61) | PPARGHDAC1HDAC3HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |