Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 3/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542516 | 0.94 | LMNA (0.49) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL4536795 | 0.89 | EPHX1 (0.54) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL4539395 | 0.89 | LMNA (0.47) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL4541867 | 0.88 | CNR1 (0.51) | LMNAEPHX1GAAHTTEPHX2 | |
| SCHEMBL4542983 | 0.87 | EPHX1 (0.57) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL4536605 | 0.87 | LMNA (0.67) | LMNAALDH1A1EPHX1TSHRALOX12 | |
| SCHEMBL4542094 | 0.87 | NPC1 (0.57) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL3917484 | 0.86 | EPHX2 (0.62) | LMNAALDH1A1GAATSHRALOX12 | |
| SCHEMBL4541877 | 0.84 | PKM (0.56) | LMNAALDH1A1EPHX1GAATSHR | |
| SCHEMBL4011026 | 0.84 | GAA (0.62) | LMNAALDH1A1EPHX1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |