Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539395 | 0.95 | LMNA (0.47) | LMNAALDH1A1GAAEPHX1TSHR | |
| SCHEMBL4540917 | 0.94 | LMNA (0.53) | LMNAALDH1A1GAAEPHX1TSHR | |
| SCHEMBL4539274 | 0.90 | CYP3A4 (0.51) | LMNAALDH1A1EPHX1TSHRALOX12 | |
| SCHEMBL4537706 | 0.88 | EPHX2 (0.48) | LMNAGAAEPHX1EPHX2MEN1 | |
| SCHEMBL4535944 | 0.88 | EPHX1 (0.52) | LMNAALDH1A1EPHX1TSHRALOX12 | |
| SCHEMBL4536776 | 0.88 | LMNA (0.62) | LMNAALDH1A1EPHX1TSHRALOX12 | |
| SCHEMBL4540431 | 0.87 | NPC1 (0.55) | LMNAALDH1A1GAAEPHX1TSHR | |
| SCHEMBL4537391 | 0.87 | EPHX1 (0.53) | LMNAALDH1A1GAAEPHX1EPHX2 | |
| SCHEMBL4543052 | 0.86 | NPC1 (0.48) | LMNAALDH1A1EPHX1TSHRALOX12 | |
| SCHEMBL4540032 | 0.85 | PKM (0.51) | LMNAALDH1A1GAAEPHX1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |