Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.34 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541510 | 1.00 | MAPT (0.50) | MAPTSMN1; SMN2LMNAHPGDUSP2 | |
| SCHEMBL4541508 | 0.86 | MAPT (0.53) | MAPTSMN1; SMN2LMNAHPGDUSP2 | |
| SCHEMBL4541506 | 0.77 | CYP2C19 (0.57) | MAPTSMN1; SMN2USP2KDM4EMEN1 | |
| SCHEMBL8943045 | 0.71 | MAPT (0.74) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL8943048 | 0.71 | MAPT (0.74) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL15829414 | 0.70 | MAPT (0.63) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL12724869 | 0.69 | MAPT (0.62) | MAPTSMN1; SMN2HPGDALDH1A1ALOX12 | |
| SCHEMBL31251637 | 0.69 | MAPT (0.62) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL20148142 | 0.69 | MAPT (0.62) | MAPTSMN1; SMN2HPGDALDH1A1ALOX12 | |
| SCHEMBL11521420 | 0.67 | MAPT (1.00) | MAPTSMN1; SMN2LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081222-A1 | SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-02 | — | — | WO | disclosed |