Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541504 | 0.86 | MAPT (0.50) | MAPTSMN1; SMN2HPGDKDM4EUSP2 | |
| SCHEMBL4541510 | 0.86 | MAPT (0.50) | MAPTSMN1; SMN2HPGDKDM4EUSP2 | |
| SCHEMBL4541506 | 0.79 | CYP2C19 (0.57) | MAPTSMN1; SMN2KDM4EUSP2CYP2C19 | |
| SCHEMBL17953132 | 0.77 | KDM4E (0.55) | HPGDKDM4EUSP2ALDH1A1CYP2C19 | |
| SCHEMBL22928144 | 0.76 | CYP2C19 (0.49) | SMN1; SMN2HPGDKDM4EUSP2ALDH1A1 | |
| SCHEMBL31251637 | 0.74 | MAPT (0.62) | MAPTSMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL28418778 | 0.74 | ALDH1A1 (0.52) | MAPTSMN1; SMN2HPGDKDM4EUSP2 | |
| SCHEMBL11599009 | 0.74 | ACHE (0.56) | HPGDKDM4EUSP2ALDH1A1CYP2C19 | |
| SCHEMBL11458014 | 0.74 | KDM4E (0.41) | MAPTSMN1; SMN2HPGDKDM4EUSP2 | |
| SCHEMBL12118572 | 0.73 | TSHR (0.58) | MAPTSMN1; SMN2HPGDKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081222-A1 | SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-02 | — | — | WO | disclosed |