Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | MMP1 | P03956 | 4/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.57 |
| ▸ | MMP9 | P14780 | 4/20 | 0.57 |
| ▸ | MAOA | P21397 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835434 | 1.00 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL28346163 | 1.00 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL733110 | 0.82 | NPSR1 (0.56) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL733111 | 0.82 | NPSR1 (0.56) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL4542528 | 0.81 | MEN1 (0.67) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL4997889 | 0.80 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL4997896 | 0.80 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL8572562 | 0.80 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL4094672 | 0.80 | TGM2 (0.66) | CYP1A2NPSR1MEN1KMT2AMAPT | |
| SCHEMBL7368786 | 0.80 | CYP1A2 (0.64) | CYP1A2NPSR1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698385-A | Preparation method and application of Isatin derivative-Isatin 1908 | 浙江海洋大学 | 2020-01-17 | — | — | CN | claimed |
| CN-110698385-A | Preparation method and application of Isatin derivative-Isatin 1908 | 浙江海洋大学 | 2020-01-17 | — | — | CN | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| CN-102898402-A | Benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound and use thereof | UNIV BEIJING | 2013-01-30 | — | — | CN | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| US-4146718-A | BLOOD PLATELET ANTIAGGREGATIVE AGENT | BRISTOL-MYERS COMPANY (US) | 1979-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | CYP1A2 636/4885NPSR1 3850/4885MEN1 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.