⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27604050 | 1.00 | — | — | |
| SCHEMBL2702499 | 1.00 | — | — | |
| Pyridine SCHEMBL27871848 | 0.84 | TGFBR1 (0.35) | — | |
| SCHEMBL27630179 | 0.81 | FOLH1 (0.34) | — | |
| SCHEMBL6746101 | 0.78 | CA2 (0.42) | — | |
| SCHEMBL13494713 | 0.78 | — | — | |
| SCHEMBL28418817 | 0.78 | — | — | |
| SCHEMBL8337750 | 0.78 | CA2 (0.42) | — | |
| SCHEMBL4130466 | 0.78 | — | — | |
| SCHEMBL4410363 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778609-A1 | NOVEL PENAM DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | FUJIFILM Corporation (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-9663488-B2 | Metalloenzyme inhibitor compounds | VIAMET PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| US-20150353546-A1 | METALLOENZYME INHIBITOR COMPOUNDS | Viamet Pharmaceuticals (NC), Inc. | 2015-12-10 | — | — | US | disclosed |
| EP-2750670-A1 | PI3K INHIBITOR FOR USE IN THE TREATMENT OF BONE CANCER OR FOR PREVENTING METASTATIC DISSEMINATION PRIMARY CANCER CELLS INTO THE BONE | Novartis AG (CH) | 2014-07-09 | — | — | EP | disclosed |
| EP-2637665-A1 | DEXAMETHASONE COMBINATION THERAPY | Board Of Regents, The University Of Texas System (US) | 2013-09-18 | — | — | EP | disclosed |
| WO-2013030368-A1 | PI3K INHIBITOR FOR USE IN THE TREATMENT OF BONE CANCER OR FOR PREVENTING METASTATIC DISSEMINATION PRIMARY CANCER CELLS INTO THE BONE | NOVARTIS AG (CH) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012065021-A1 | DEXAMETHASONE COMBINATION THERAPY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-1984350-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | Novartis AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084786-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-07-26 | — | — | WO | disclosed |
| EP-0276124-B1 | PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Sankyo Company Limited (JP) | 1992-05-20 | — | — | EP | disclosed |
| US-4981872-A | ANTIULCER | SANKYO COMPANY LIMITED (JP) | 1991-01-01 | — | — | US | disclosed |
| EP-0276124-A2 | Prostaglandin derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1988-07-27 | — | — | EP | disclosed |