Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 16/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 16/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537521 | 0.95 | LMNA (0.54) | EPHX1EPHX2LMNAUSP2 | |
| SCHEMBL4536850 | 0.89 | EPHX1 (0.52) | EPHX1EPHX2LMNAUSP2 | |
| SCHEMBL4542200 | 0.89 | LMNA (0.54) | EPHX1EPHX2LMNA | |
| SCHEMBL8062904 | 0.89 | EPHX2 (0.59) | EPHX1EPHX2 | |
| SCHEMBL4537048 | 0.87 | LMNA (0.47) | EPHX1EPHX2LMNAUSP2 | |
| SCHEMBL4537741 | 0.87 | EPHX2 (0.44) | EPHX2LMNA | |
| SCHEMBL4537187 | 0.84 | EPHX1 (0.52) | EPHX1EPHX2LMNAUSP2 | |
| SCHEMBL4540068 | 0.84 | EPHX1 (0.54) | EPHX1EPHX2LMNAUSP2 | |
| SCHEMBL4537966 | 0.84 | LMNA (0.57) | EPHX1EPHX2LMNA | |
| SCHEMBL4539990 | 0.84 | USP2 (0.56) | EPHX1EPHX2LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |