Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530583 | 0.95 | EPHX2 (0.46) | EPHX2MEN1KMT2AGAALMNA | |
| SCHEMBL4541162 | 0.89 | EPHX2 (0.50) | EPHX2MEN1KMT2AGAALMNA | |
| SCHEMBL4539368 | 0.89 | KMT2A (0.46) | MEN1KMT2AGAALMNAHTT | |
| SCHEMBL4535419 | 0.89 | KMT2A (0.49) | KMT2AGAALMNATP53TSHR | |
| SCHEMBL4542593 | 0.87 | EPHX1 (0.50) | EPHX2LMNA | |
| SCHEMBL8068258 | 0.86 | EPHX2 (0.40) | EPHX2MEN1KMT2AGAALMNA | |
| SCHEMBL4541251 | 0.86 | EPHX2 (0.45) | EPHX2MEN1KMT2AGAALMNA | |
| SCHEMBL8053633 | 0.85 | ALDH1A1 (0.43) | MEN1KMT2AGAALMNAALDH1A1 | |
| SCHEMBL4535853 | 0.84 | FBP1 (0.46) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8048322 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2AGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |