Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sanguinarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.91 |
| ▸ | MAPT | P10636 | 6/20 | 0.91 |
| ▸ | HPGD | P15428 | 6/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.91 |
| ▸ | TP53 | P04637 | 3/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.91 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.91 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.91 |
| ▸ | RGS12 | O14924 | 2/20 | 0.91 |
| ▸ | BAD | Q92934 | 7/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.88 |
| ▸ | MEN1 | O00255 | 4/20 | 0.88 |
| ▸ | LMNA | P02545 | 4/20 | 0.88 |
| ▸ | ACHE | P22303 | 4/20 | 0.88 |
| ▸ | BCHE | P06276 | 3/20 | 0.88 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sanguinarium SCHEMBL123241 | 0.94 | BAD (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL23524622 | 0.94 | BAD (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL30129850 | 0.94 | BAD (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL29385229 | 0.94 | BAD (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL30153784 | 0.94 | BAD (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL43290 | 0.93 | RAC1 (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL30668087 | 0.93 | RAC1 (1.00) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL8937106 | 0.93 | BAD (0.97) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL8584009 | 0.93 | BAD (0.97) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 | |
| Sanguinarium SCHEMBL1463519 | 0.92 | BAD (0.86) | ALDH1A1MAPTHPGDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590463-B | Fertilizer and molluscicide double-effect organic fertilizer molluscicide, preparation method and application thereof | 湖北大学 | 2021-10-15 | — | — | CN | claimed |
| EP-3829640-A1 | METHODS FOR INHIBITING MICROBE GROWTH | McMaster University (CA) | 2021-06-09 | — | — | EP | claimed |
| WO-2020024060-A1 | METHODS FOR INHIBITING MICROBE GROWTH | MCMASTER UNIVERSITY (CA) | 2020-02-06 | — | — | WO | claimed |
| CN-110590463-A | Fertilizer and molluscicide double-effect organic fertilizer molluscicide, preparation method and application thereof | 湖北大学 | 2019-12-20 | — | — | CN | claimed |
| EP-3500271-A1 | GENOME EDITING ENHANCERS | Bluebird Bio, Inc. (US) | 2019-06-26 | — | — | EP | claimed |
| US-20190169597-A1 | GENOME EDITING ENHANCERS | BLUEBIRD BIO, INC. (US) | 2019-06-06 | — | — | US | claimed |
| WO-2018035423-A1 | GENOME EDITING ENHANCERS | BLUEBIRD BIO, INC. (US) | 2018-02-22 | — | — | WO | claimed |
| US-20160082073-A1 | NOVEL USE | HELPERBY THERAPEUTICS LIMITED (GB) | 2016-03-24 | — | — | US | claimed |
| US-20130243886-A1 | NOVEL USE | HELPERBY THERAPEUTICS LIMITED (GB) | 2013-09-19 | — | — | US | claimed |
| EP-2613774-A2 | NOVEL USE | Helperby Therapeutics Limited (GB) | 2013-07-17 | — | — | EP | claimed |
| WO-2012032360-A2 | NOVEL USE | HELPERBY THERAPEUTICS LIMITED (GB) | 2012-03-15 | — | — | WO | claimed |
| EP-0149409-B1 | PLATE DISCLOSING AGENT | VIPONT PHARMACEUTICAL, INC. (US) | 1991-04-10 | — | — | EP | claimed |
| US-4517172-A | SANGUINARINE SALTS, ULTRAVILET LIGHT | VIPONT LABORATORIES, INC. (US) | 1985-05-14 | — | — | US | claimed |
| CN-121845075-A | Pesticide composition and preparation method and application thereof | 河北农信生物科技有限责任公司 | 2026-04-14 | — | — | CN | disclosed |
| CN-118714927-A | Compositions and methods for controlling phytopathogenic infection | 法国国家农业食品与环境研究院 | 2024-09-27 | — | — | CN | disclosed |
| WO-2024189607-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT | DIDENKO KIRILL (MX) | 2024-09-19 | — | — | WO | disclosed |
| US-4599228-A | Antimicrobial agent | VIPONT LABORATORIES, INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4590061-A | BENZO-C-PHENANTHRIDINE ALKALOIDS | VIPONT LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4517172-A | SANGUINARINE SALTS, ULTRAVILET LIGHT | VIPONT LABORATORIES, INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4406881-A | ANTICARIES AGENTS, ALKALOIDS | VIPONT LABORATORIES (US) | 1983-09-27 | — | — | US | disclosed |