SCHEMBL4543083

SCHEMBL4543083

Cc1ccc2sc3cccc(C(=O)N(CC(C)C)CC(C)C)c3c(=O)c2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.42
ALDH1A1 P00352 4/20 0.42
POLB P06746 2/20 0.42
KDM4E B2RXH2 2/20 0.42
TDP1 Q9NUW8 1/20 0.36
RAD52 P43351 1/20 0.36
TP53 P04637 1/20 0.36
BCHE P06276 4/20 0.36
MAPT P10636 3/20 0.36
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
LMNA P02545 1/20 0.36
GLA P06280 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
ATM Q13315 1/20 0.35
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28806848 0.84 HPGD (0.36) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL4539088 0.80 MLYCD (0.40) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL30748204 0.80 MLYCD (0.40) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL4542795 0.80 ALDH1A1 (0.49) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL4537030 0.78 ALDH1A1 (0.51) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL29000291 0.76 ALDH1A1 (0.49) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL3248484 0.72 ALDH1A1 (0.51) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL4536611 0.71 ALDH1A1 (0.50) HPGDALDH1A1POLBKDM4ETDP1
SCHEMBL10988178 0.70 TP53 (0.46) HPGDALDH1A1POLBKDM4ETP53
SCHEMBL26650575 0.67 POLB (0.38) HPGDALDH1A1POLBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638027-B1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA SRL (IT) 2016-07-13 EP disclosed
EP-2638027-B1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA SRL (IT) 2016-07-13 EP disclosed
CN-103209974-B Low-extractable thioxanthones LAMBERTI SPA 2015-04-15 CN disclosed
US-8933142-B2 Low-extractable thioxanthones LAMBERTI SPA (IT) 2015-01-13 US disclosed
US-8933142-B2 Low-extractable thioxanthones LAMBERTI SPA (IT) 2015-01-13 US disclosed
US-8933142-B2 Low-extractable thioxanthones LAMBERTI SPA (IT) 2015-01-13 US disclosed
EP-2638027-A1 LOW-EXTRACTABLE THIOXANTHONES Lamberti SpA (IT) 2013-09-18 EP disclosed
US-20130237628-A1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA S.R.L. (IT) 2013-09-12 US disclosed
US-20130237628-A1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA S.R.L. (IT) 2013-09-12 US disclosed
US-20130237628-A1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA S.R.L. (IT) 2013-09-12 US disclosed
CN-103209974-A Low-extractable thioxanthones LAMBERTI SPA 2013-07-17 CN disclosed
WO-2012062692-A1 LOW-EXTRACTABLE THIOXANTHONES LAMBERTI SPA (IT) 2012-05-18 WO disclosed
WO-2012062692-A1 LOW-EXTRACTABLE THIOXANTHONES LAMBERTI SPA (IT) 2012-05-18 WO disclosed