Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.57 |
| ▸ | DRD3 | P35462 | 11/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7201980 | 0.99 | DRD2 (0.56) | DRD2DRD3DRD4OPRM1KCNH2 | |
| SCHEMBL4389062 | 0.83 | DRD3 (0.63) | DRD2DRD3DRD4KCNH2HTR1A | |
| SCHEMBL4395639 | 0.81 | HTR7 (0.43) | DRD2DRD3KCNH2HTR1AHTR2A | |
| SCHEMBL4381610 | 0.78 | KDM4E (0.44) | DRD2DRD3KCNH2HTR7HTR2B | |
| SCHEMBL4392739 | 0.77 | HTT (0.42) | DRD2DRD3KCNH2 | |
| SCHEMBL4766034 | 0.77 | DRD3 (0.70) | DRD2DRD3DRD4KCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL7199896 | 0.76 | HTT (0.41) | DRD2DRD3KCNH2 | |
| SCHEMBL3348927 | 0.74 | DRD2 (1.00) | DRD2DRD3DRD4OPRM1HTR1A | |
| SCHEMBL7844061 | 0.73 | DRD2 (0.74) | DRD2DRD3DRD4OPRM1HTR1A | |
| SCHEMBL6979746 | 0.70 | DRD3 (0.74) | DRD2DRD3DRD4OPRM1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | disclosed |