Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552839 | 0.87 | HDAC8 (0.44) | AKT1CTSAMAPK1HDAC8PORCN | |
| SCHEMBL3330673 | 0.82 | AKT1 (0.43) | AKT1CTSANTRK1MAPK1SCN9A | |
| SCHEMBL21980547 | 0.82 | AKT1 (0.43) | AKT1CTSANTRK1MAPK1SCN9A | |
| SCHEMBL4439796 | 0.82 | HDAC3 (0.38) | AKT1SCN9ASCN10AANO1MEN1 | |
| SCHEMBL4543363 | 0.81 | AKT1 (0.39) | AKT1NTRK1MAPK1SCN9ASCN10A | |
| SCHEMBL3329760 | 0.81 | NTRK1 (0.37) | AKT1CTSANTRK1MAPK1SCN9A | |
| SCHEMBL3329764 | 0.81 | NTRK1 (0.37) | AKT1CTSANTRK1MAPK1SCN9A | |
| SCHEMBL13300021 | 0.79 | SCN9A (0.43) | AKT1NTRK1MAPK1SCN9ASCN10A | |
| SCHEMBL4554107 | 0.77 | HDAC8 (0.45) | MAPK1HDAC8PORCNCTSVCTSL | |
| SCHEMBL4543975 | 0.75 | NTRK1 (0.34) | NTRK1MAPK1SCN9ASCN10AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |