Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAT | P00750 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CD44 | P16070 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544279 | 0.94 | MELK (0.48) | MELKPNMTADRA2AADRA2BADRA2C | |
| Trifluoroacetic Acid SCHEMBL31335937 | 0.85 | MELK (0.44) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL30527844 | 0.84 | PLAU (0.53) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL1119301 | 0.84 | PLAU (0.53) | PLAUF2PLGPLATKLKB1 | |
| Hydrochloric Acid SCHEMBL1028250 | 0.83 | PLAU (0.52) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL4544259 | 0.82 | ASIC3 (0.47) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL30428318 | 0.79 | ALDH1A1 (0.59) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL30357006 | 0.79 | ALDH1A1 (0.59) | PLAUADRA2AADRA2BADRA2C | |
| SCHEMBL1026101 | 0.79 | ALDH1A1 (0.59) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL1013707 | 0.78 | NPC1 (0.53) | PLAUF2PLGPLATKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120910-A2 | HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF | Novartis Ag (CH) | 2009-11-25 | — | — | EP | claimed |
| WO-2008076954-A2 | HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF | NOVARTIS AG (CH) | 2008-06-26 | — | — | WO | claimed |