Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544153 | 0.89 | RAF1 (0.55) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL4541536 | 0.87 | BRAF (0.43) | MAPK14RAF1BRAFCNR2PLAU | |
| SCHEMBL14473262 | 0.85 | RAF1 (0.54) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL14473260 | 0.80 | RAF1 (0.53) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL5603871 | 0.77 | BRAF (0.41) | RAF1BRAFPLAU | |
| SCHEMBL4541538 | 0.77 | RAF1 (0.56) | MAPK14RAF1BRAF | |
| SCHEMBL5593458 | 0.76 | BRAF (0.61) | MAPK14RAF1BRAF | |
| SCHEMBL4566569 | 0.75 | RAF1 (0.55) | MAPK14MAPK13HSPB1MAPK12MAPK11 | |
| SCHEMBL4551381 | 0.75 | RAB9A (0.53) | RAF1BRAFPLAUCYP1A2CYP2C19 | |
| SCHEMBL4541525 | 0.75 | ACKR3 (0.44) | MAPK14RAF1BRAFPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |