Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | FGB | P02675 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202115 | 0.73 | KMT2A (0.44) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL12403313 | 0.72 | KMT2A (0.42) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6974296 | 0.71 | TDP1 (0.43) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL17117210 | 0.71 | SMN1; SMN2 (0.41) | KMT2AMAPTKDM4EGAAALDH1A1 | |
| SCHEMBL8748376 | 0.70 | HTR2C (0.51) | KMT2AMEN1MAPTKDM4EL3MBTL1 | |
| SCHEMBL31525035 | 0.70 | HSD17B10 (0.47) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL3253975 | 0.70 | HSD17B10 (0.47) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL10549056 | 0.70 | TP53 (0.43) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL5674530 | 0.70 | KMT2A (0.41) | TDP1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL227751 | 0.68 | SLC6A2 (0.47) | TDP1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7629463-B2 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-12-08 | — | — | US | disclosed |
| US-20080132524-A1 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | CLARK DAVID ALAN | 2008-06-05 | — | — | US | disclosed |
| US-7375232-B2 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| EP-1417204-B1 | ORTHO-HETEROCYCLIC SUBSTITUTED ARYL AMIDES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20040242645-A1 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132524-A1 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | AOC2, DDT, CBR3 | TDP1 3431/4885KMT2A 1754/4885MEN1 3976/4885 |
| US-20040242645-A1 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | AOC2, OLA1, AOC3 | TDP1 2827/4885KMT2A 2223/4885MEN1 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.