SCHEMBL4544836

SCHEMBL4544836

Clc1cccc(Nc2nc(Nc3ccccc3)nc(Nc3cccc(Cl)c3)n2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.66
MAPT P10636 3/20 0.66
MEN1 O00255 3/20 0.66
MAPK1 P28482 1/20 0.66
NFKB1 P19838 1/20 0.60
RHOA P61586 1/20 0.57
IDH2 P48735 1/20 0.57
GAA P10253 2/20 0.57
ADORA2A P29274 1/20 0.56
LMNA P02545 1/20 0.56
KDM4E B2RXH2 1/20 0.55
FADS1 O60427 1/20 0.54
SYK P43405 1/20 0.54
EGFR P00533 1/20 0.54
KCNH3 Q9ULD8 1/20 0.53
NPC1 O15118 1/20 0.51
RAB9A P51151 1/20 0.51
ABCG2 Q9UNQ0 2/20 0.51
PDE5A O76074 1/20 0.51
ABCB1 P08183 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12154881 0.92 KMT2A (0.56) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL24726686 0.87 KCNH3 (0.74) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL4544831 0.86 APP (0.62) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL3951892 0.86 MEN1 (0.68) KMT2AMAPTMEN1MAPK1GAA
SCHEMBL30342506 0.86 MEN1 (0.68) KMT2AMAPTMEN1MAPK1GAA
SCHEMBL12963090 0.85 HTR1A (0.50) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL8526184 0.85 NFKB1 (0.69) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL4544792 0.84 NFKB1 (0.73) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL4544826 0.84 NFKB1 (0.73) KMT2AMAPTMEN1MAPK1NFKB1
SCHEMBL2590759 0.83 NPY5R (0.76) KMT2AMAPTMEN1MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9223070-B2 Optical film, polarizing plate equipped with the optical film, process for manufacture of the polarizing plate, and liquid crystal display device Konica Minolta, Inc. (JP) 2015-12-29 US disclosed
US-20150253480-A1 RETARDATION FILM, ELONGATED CIRCULARLY POLARIZING PLATE AND ORGANIC EL DISPLAY PRODUCED USING SAID RETARDATION FILM Konica Minolta, Inc. (JP) 2015-09-10 US disclosed
US-9110243-B2 Laminate film, optically compensatory film, polarizing plate, and liquid crystal display device FUJIFILM CORPORATION (JP) 2015-08-18 US disclosed
US-9103988-B2 Liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-08-11 US disclosed
US-8976325-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-03-10 US disclosed
US-8947621-B2 Liquid crystal display device comprising a front plate having a lamda/4 plate that includes a hard coat layer and method for manufacturing the same KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2015-02-03 US disclosed
US-8681295-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2014-03-25 US disclosed
US-20130293812-A1 OPTICAL FILM, POLARIZING PLATE EQUIPPED WITH THE OPTICAL FILM, PROCESS FOR MANUFACTURE OF THE POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE Konica Minolta, Inc. (JP) 2013-11-07 US disclosed
US-20130169897-A1 METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2013-07-04 US disclosed
US-8477273-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2013-07-02 US disclosed
US-20080174724-A1 Liquid crystal display device, optical film and polarizing plate FUJIFILM CORPORATION (JP) 2008-07-24 US disclosed
US-20080158488-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-07-03 US disclosed
US-20080158488-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-07-03 US disclosed
US-20080143928-A1 Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-19 US disclosed
US-20080143928-A1 Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-19 US disclosed
US-20080137014-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-12 US disclosed
US-20080137014-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-12 US disclosed
US-20080013173-A1 METHOD OF MANUFACTURING A POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2008-01-17 US disclosed
US-20080013173-A1 METHOD OF MANUFACTURING A POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2008-01-17 US disclosed
WO-2007023990-A1 LIQUID CRYSTAL DISPLAY DEVICE FUJI FILM CORPORATION (JP) 2007-03-01 WO disclosed