SCHEMBL4544845

SCHEMBL4544845

CCOC(=O)c1ccc(Nc2nc(Nc3ccc(C(=O)OCC)cc3)nc(Nc3cccc(C)c3)n2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.70
KMT2A Q03164 5/20 0.70
RAB9A P51151 3/20 0.70
THRB P10828 1/20 0.70
SMN1; SMN2 Q16637 4/20 0.65
NPC1 O15118 3/20 0.65
KDM4E B2RXH2 3/20 0.65
PDPK1 O15530 1/20 0.64
SLC2A1 P11166 1/20 0.59
HTT P42858 1/20 0.58
EGFR P00533 1/20 0.56
ERBB3 P21860 1/20 0.56
MAPT P10636 4/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
TP53 P04637 2/20 0.54
GBA1 P04062 1/20 0.53
HPGD P15428 2/20 0.52
RXFP1 Q9HBX9 1/20 0.52
ALDH1A1 P00352 3/20 0.52
CASP3 P42574 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4544778 1.00 MEN1 (0.70) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL4544865 0.97 MEN1 (0.67) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL4544868 0.97 MEN1 (0.67) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL13799941 0.95 MEN1 (0.64) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL10033677 0.91 MEN1 (0.59) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL12253193 0.88 MEN1 (0.83) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL4544848 0.86 KMT2A (0.76) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL4544815 0.81 CDC25B (0.57) MEN1KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL13852878 0.81 MEN1 (0.72) MEN1KMT2ARAB9ATHRBSMN1; SMN2
SCHEMBL28141853 0.81 RAB9A (0.67) MEN1KMT2ARAB9ATHRBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9223070-B2 Optical film, polarizing plate equipped with the optical film, process for manufacture of the polarizing plate, and liquid crystal display device Konica Minolta, Inc. (JP) 2015-12-29 US disclosed
US-20150253480-A1 RETARDATION FILM, ELONGATED CIRCULARLY POLARIZING PLATE AND ORGANIC EL DISPLAY PRODUCED USING SAID RETARDATION FILM Konica Minolta, Inc. (JP) 2015-09-10 US disclosed
US-9110243-B2 Laminate film, optically compensatory film, polarizing plate, and liquid crystal display device FUJIFILM CORPORATION (JP) 2015-08-18 US disclosed
US-9103988-B2 Liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-08-11 US disclosed
US-8976325-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-03-10 US disclosed
US-20150033984-A1 CELLULOSE ACYLATE FILM, POLARIZING PLATE, MANUFACTURING METHOD OF POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2015-02-05 US disclosed
US-8947621-B2 Liquid crystal display device comprising a front plate having a lamda/4 plate that includes a hard coat layer and method for manufacturing the same KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2015-02-03 US disclosed
US-8681295-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2014-03-25 US disclosed
US-20130293812-A1 OPTICAL FILM, POLARIZING PLATE EQUIPPED WITH THE OPTICAL FILM, PROCESS FOR MANUFACTURE OF THE POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE Konica Minolta, Inc. (JP) 2013-11-07 US disclosed
US-20130169897-A1 METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2013-07-04 US disclosed
US-20100020273-A1 POLYMER FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY FUJIFILM CORPORATION (JP) 2010-01-28 US disclosed
US-7611760-B2 Cellulose acylate film, optical compensation film, polarizing plate and liquid crystal display FUJIFILM CORPORATION (JP) 2009-11-03 US disclosed
US-20090251650-A1 Liquid crystal display device FUJIFILM CORPORATION (JP) 2009-10-08 US disclosed
US-20090080074-A1 POLYMER FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2009-03-26 US disclosed
US-20090066887-A1 Polymer Film, Polarizing Plate Protective Film, Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2009-03-12 US disclosed
US-20080204644-A1 Liquid crystal display device FUJIFILM CORPORATION (JP) 2008-08-28 US disclosed
US-20080198303-A1 Polarizing plate and liquid crystal display device FUJIFILM CORPORATION (JP) 2008-08-21 US disclosed
US-20080143928-A1 Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-19 US disclosed
US-20080137014-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-12 US disclosed
US-20080013173-A1 METHOD OF MANUFACTURING A POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2008-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090080074-A1 POLYMER FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE RPA3, RTF1, RPA1 MEN1 2012/4885KMT2A 3282/4885RAB9A 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.