Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.69 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.49 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269815 | 0.82 | OPRL1 (1.00) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL10216610 | 0.81 | OPRL1 (0.67) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL4546499 | 0.68 | OPRL1 (0.78) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL550284 | 0.67 | OPRL1 (0.84) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL16372421 | 0.66 | OPRM1 (0.52) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL1272305 | 0.66 | OPRL1 (0.70) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL853891 | 0.66 | OPRM1 (1.00) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL4546475 | 0.66 | OPRL1 (0.80) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL4546351 | 0.65 | OPRL1 (0.50) | OPRM1OPRL1OPRD1OPRK1OGFRL1 | |
| SCHEMBL7741794 | 0.65 | ALDH1A1 (0.45) | OPRM1OPRL1OPRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637502-B2 | 2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain | Purde Pharma L.P. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120108575-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-8110602-B2 | Compounds comprising heterocyclic-substituted piperidine for treating pain | PURDUE PHARMA L.P. (US) | 2012-02-07 | — | — | US | disclosed |
| US-20100022519-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022519-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | TRPV1, P2RX4, TRPA1 | OPRM1 17/4885OPRL1 6/4885OPRD1 16/4885 |
| US-20120108575-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | TRPV1, P2RX4, TRPA1 | OPRM1 17/4885OPRL1 6/4885OPRD1 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.