Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 20/20 | 0.64 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4546693 | 0.91 | HCAR2 (0.67) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1566902 | 0.83 | HCAR2 (0.64) | HCAR2 | |
| SCHEMBL1567012 | 0.82 | HCAR2 (0.62) | HCAR2 | |
| SCHEMBL1567372 | 0.79 | HCAR2 (0.67) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL17503035 | 0.79 | HCAR2 (0.66) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1566645 | 0.79 | HCAR2 (0.66) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1567506 | 0.78 | HCAR2 (0.65) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1567973 | 0.77 | HCAR2 (0.67) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1567794 | 0.77 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL1566851 | 0.77 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150563-B2 | Nitrogen-containing aromatic heterocyclyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20140187592-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-07-03 | — | — | US | disclosed |
| US-8648103-B2 | Nitrogen-containing aromatic heterocyclyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-02-11 | — | — | US | disclosed |
| US-20120108639-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187592-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND | NPR1, NPR3, NPC1 | HCAR2 580/4885CYP2C8 364/4885CYP2C9 196/4885 |
| US-20120108639-A1 | NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND | NPR1, NPR3, NPPA | HCAR2 526/4885CYP2C8 163/4885CYP2C9 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.