⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23199282 | 0.97 | GABRA5 (0.40) | — | |
| SCHEMBL21686127 | 0.85 | — | — | |
| SCHEMBL25455590 | 0.85 | — | — | |
| Propionic Acid SCHEMBL27306342 | 0.84 | GABRA5 (0.48) | — | |
| Tert-Butyl Formate SCHEMBL27595539 | 0.81 | TDP1 (0.45) | — | |
| SCHEMBL76463 | 0.80 | — | — | |
| SCHEMBL30816862 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL7138787 | 0.78 | GBA1 (0.38) | — | |
| SCHEMBL6379288 | 0.77 | — | — | |
| SCHEMBL2409711 | 0.75 | GABRA5 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104710408-A | Chiral cis-imidazolines | HOFFMANN LA ROCHE | 2015-06-17 | — | — | CN | claimed |
| CN-101821251-A | Chiral cis-imidazolines | HOFFMANN LA ROCHE | 2010-09-01 | — | — | CN | claimed |
| CN-101316823-A | 2,4, 5-triphenylimidazoline derivatives as inhibitors of the interaction between p53 and MDM2 proteins for use as anticancer agents | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | claimed |
| CN-1800163-A | Dissymmetrical diazo compounds comprising 2-pyridinium group and a cationic or non-cationic linker, compositions comprising them, method for coloring, and device | OREAL (FR) | 2006-07-12 | — | — | CN | claimed |
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| WO-2025049820-A1 | STAT6 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| EP-4499628-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2025-02-05 | — | — | EP | disclosed |
| CN-111777593-B | Novel compounds as inhibitors of rearrangement kinase during transfection | 南京天印健华医药科技有限公司 | 2024-07-23 | — | — | CN | disclosed |
| WO-2024130161-A2 | NOVEL CAMPTOTHECIN DERIVATIVES AND CONJUGATES THEREOF | BIONECURE THERAPEUTICS INC (US) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024121290-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED (GB) | 2024-06-13 | — | — | WO | disclosed |
| CN-117964623-A | Targeted protein degradation compound and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2024083258-A1 | KRAS G12C DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | 上海领泰生物医药科技有限公司 | 2024-04-25 | — | — | WO | disclosed |
| CN-1034015-C | Process to prepare cycloamine compounds | EISAI CO LTD (JP) | 1997-02-12 | — | — | CN | disclosed |
| CN-1024547-C | Preparation method of cyclic amine compound | EISAI CO LTD (JP) | 1994-05-18 | — | — | CN | disclosed |
| CN-1073939-A | A kind of preparation method of cyclic amine compound | EISAI CO LTD (JP) | 1993-07-07 | — | — | CN | disclosed |
| CN-1071417-A | The preparation method of cyclic amine compound | EISAI CO LTD (JP) | 1993-04-28 | — | — | CN | disclosed |
| EP-0418933-A1 | Derivatives of alcadienes, their preparations and medicinal compositions containing them and intermediates | RHONE-POULENC SANTE (FR) | 1991-03-27 | — | — | EP | disclosed |
| EP-0333071-A2 | Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use | Eisai Co., Ltd. (JP) | 1989-09-20 | — | — | EP | disclosed |
| EP-0310484-A1 | Derivatives of alkadienes, their preparations, medicinal compositions containing them, and intermediates | RHONE-POULENC SANTE (FR) | 1989-04-05 | — | — | EP | disclosed |
| CN-1030752-A | Preparation method of cyclic amine compound | EISAI CO LTD (JP) | 1989-02-01 | — | — | CN | disclosed |