Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22016241 | 0.86 | TNF (0.43) | TNFGRM4 | |
| SCHEMBL4552885 | 0.82 | TNF (0.40) | TNF | |
| SCHEMBL4547799 | 0.74 | SMN1; SMN2 (0.39) | GRM4 | |
| SCHEMBL22016242 | 0.68 | GRM4 (0.44) | GRM4 | |
| SCHEMBL22017499 | 0.68 | LMNA (0.39) | — | |
| SCHEMBL5465654 | 0.67 | ALDH1A1 (0.59) | TNFGRM4 | |
| SCHEMBL4547804 | 0.67 | GRM4 (0.34) | GRM4 | |
| SCHEMBL25468120 | 0.66 | PI4KA (0.41) | — | |
| SCHEMBL21676714 | 0.66 | TNF (0.37) | TNFGRM4 | |
| SCHEMBL22016238 | 0.65 | FEN1 (0.63) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501749-B2 | Azaquinazolinediones chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-06 | — | — | US | disclosed |
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108597-A1 | Azaquinazolinediones Chymase Inhibitors | CMA1, SERPINB1, CTSC | TNF 3006/4885GRM4 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.