Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935233 | 0.85 | CYP1A2 (0.50) | CYP3A4CYP2C19CYP1A2CYP2C9RECQL | |
| SCHEMBL4547959 | 0.84 | CYP1A2 (0.53) | CYP3A4CYP2C19ADORA2ACYP1A2CYP2C9 | |
| SCHEMBL4547981 | 0.83 | ALOX15 (0.48) | CYP3A4CYP2C19CYP1A2CYP2C9RECQL | |
| SCHEMBL24072353 | 0.80 | CYP3A4 (0.81) | CYP3A4CYP2C19ADORA2ACYP1A2HPGD | |
| SCHEMBL30339046 | 0.80 | CYP3A4 (0.81) | CYP3A4CYP2C19ADORA2ACYP1A2HPGD | |
| SCHEMBL4547991 | 0.78 | MGAM (0.47) | CYP3A4CYP2C19CYP1A2CYP2C9RECQL | |
| SCHEMBL4547961 | 0.77 | DHODH (0.63) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1936726 | 0.77 | LMNA (0.51) | CYP1A2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4547963 | 0.75 | GCK (0.44) | ALDH1A1SMN1; SMN2L3MBTL1POLBMAPT | |
| SCHEMBL29908280 | 0.74 | HPGD (0.67) | CYP3A4CYP2C19ADORA2ACYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | CYP3A4 1060/4885CYP2C19 1118/4885ADORA2A 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.