Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 8/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.39 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936892 | 0.89 | ALK (0.40) | WNT3ATRPV4POLBSMN1; SMN2NPSR1 | |
| SCHEMBL4547984 | 0.87 | KCNH2 (0.42) | WNT3ASMN1; SMN2CNR2ABL1KCNH2 | |
| SCHEMBL4547963 | 0.86 | GCK (0.44) | TRPV4ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4547996 | 0.84 | WDR5 (0.40) | WNT3ATRPV4SMN1; SMN2NPSR1ALK | |
| SCHEMBL4547993 | 0.84 | WDR5 (0.40) | TRPV4SMN1; SMN2NPSR1ALKGCK | |
| SCHEMBL4547981 | 0.77 | ALOX15 (0.48) | KDM4EALDH1A1LMNAPOLBGAA | |
| SCHEMBL4547999 | 0.76 | ALK (0.40) | WNT3ATRPV4SMN1; SMN2NPSR1ALK | |
| SCHEMBL1937414 | 0.75 | JAK2 (0.43) | ALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL4547983 | 0.73 | MEN1 (0.47) | KDM4EALDH1A1POLBGAAMAPT | |
| SCHEMBL4548009 | 0.73 | WDR5 (0.40) | WNT3ATRPV4ALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | WNT3A 3247/4885CSNK1E 3270/4885CSNK1G3 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.