SCHEMBL454800

SCHEMBL454800

O=C(O)[C@](O)(Cc1ccccc1)N(O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.52
HIF1A Q16665 1/20 0.52
FDPS P14324 1/20 0.46
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP1A2 P05177 1/20 0.45
CES1 P23141 2/20 0.40
CES2 O00748 1/20 0.40
AKR1B1 P15121 1/20 0.40
MMP8 P22894 1/20 0.40
ALOX5 P09917 4/20 0.40
RIPK1 Q13546 1/20 0.39
ARG1 P05089 1/20 0.38
ARG2 P78540 1/20 0.38
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP3A4 P08684 1/20 0.38
KEAP1 Q14145 1/20 0.38
SLC6A2 P23975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28132469 0.85 SMN1; SMN2 (0.48) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL1325186 0.84 SMN1; SMN2 (0.57) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL6834107 0.83 SMN1; SMN2 (0.47) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL31745420 0.82 SMN1; SMN2 (0.46) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL3863998 0.79 SMN1; SMN2 (0.47) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL9137764 0.75 FDPS (0.50) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL5031234 0.74 HIF1A (0.50) SMN1; SMN2HIF1ACYP2C9CYP2C19CYP1A2
SCHEMBL29112713 0.74 SMN1; SMN2 (0.50) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL3736878 0.74 SMN1; SMN2 (0.50) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19
SCHEMBL30887346 0.74 SMN1; SMN2 (0.50) SMN1; SMN2HIF1AFDPSCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270429-A1 PROTEIN-BASED ADHESIVE AND ITS MODIFICATION PURDUE RESEARCH FOUNDATION (US) 2025-08-28 US claimed
US-12331230-B2 Protein-based adhesive and its modification PURDUE RESEARCH FOUNDATION 2025-06-17 US claimed
US-20210207013-A1 PROTEIN-BASED ADHESIVE AND ITS MODIFICATION PURDUE RESEARCH FOUNDATION (US) 2021-07-08 US claimed
WO-2020041557-A1 PROTEIN-BASED ADHESIVE AND ITS MODIFICATION PURDUE RESEARCH FOUNDATION (US) 2020-02-27 WO claimed
US-20190201349-A1 CAPSULES AND PARTICLES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2019-07-04 US claimed
WO-2017072759-A1 CAPSULES AND PARTICLES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2017-05-04 WO claimed
EP-2306192-B1 Risk Markers For Cardiovascular Disease CLEVELAND CLINIC FOUNDATION (US) 2015-10-14 EP claimed
US-9005904-B2 Risk markers for cardiovascular disease THE CLEVELAND CLINIC FOUNDATION (US) 2015-04-14 US claimed
US-20150037905-A1 RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2015-02-05 US claimed
US-8722344-B2 Risk markers for cardiovascular disease THE CLEVELAND CLINIC FOUNDATION (US) 2014-05-13 US claimed
EP-2306192-A2 Risk Markers For Cardiovascular Disease The Cleveland Clinic Foundation (US) 2011-04-06 EP claimed
EP-2268305-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE The Cleveland Clinic Foundation (US) 2011-01-05 EP claimed
US-7781219-B2 determining levels of one or more oxidized apolipoprotien A-I related biomolecules in a bodily sample; atherosclerosis THE CLEVELAND CLINIC FOUNDATION (US) 2010-08-24 US claimed
US-20100183607-A1 RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2010-07-22 US claimed
WO-2009114875-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2009-09-17 WO claimed
EP-1697746-A4 RISK MARKERS FOR CARDIOVASCULAR DISEASE CLEVELAND CLINIC FOUNDATION (US) 2007-08-29 EP claimed
EP-1697746-A2 RISK MARKERS FOR CARDIOVASCULAR DISEASE The Cleveland Clinic Foundation (US) 2006-09-06 EP claimed
US-20050239136-A1 Risk markers for cardiovacular disease THE CLEVELAND CLINIC FOUNDATION 2005-10-27 US claimed
WO-2005055810-A2 RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2005-06-23 WO claimed
US-5047344-A Alteromonas Bacteria To Attract Oyster Larvae RESEARCH CORPORATION TECHNIQUES, INC. (US) 1991-09-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190201349-A1 CAPSULES AND PARTICLES AND USES THEREOF ALG1, LPO, FUT5 SMN1; SMN2 4359/4885HIF1A 3448/4885FDPS 611/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.