Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MGAM | O43451 | 3/20 | 0.47 |
| ▸ | SI | P14410 | 3/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548007 | 0.93 | NPC1 (0.45) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL1936924 | 0.89 | CYP1A2 (0.50) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL4547991 | 0.86 | MGAM (0.47) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL4548004 | 0.84 | GRM5 (0.45) | GAANPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL4548001 | 0.81 | ALOX15 (0.48) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL12673314 | 0.80 | PARP1 (0.48) | GAAMGAMSIMGAM2NPC1 | |
| SCHEMBL4547959 | 0.78 | CYP1A2 (0.53) | GAANPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL4548005 | 0.78 | WDR5 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4548008 | 0.76 | GRM5 (0.45) | GAANPC1RAB9ACYP1A2ALDH1A1 | |
| SCHEMBL12673320 | 0.75 | PARP1 (0.48) | GAAMGAMSIMGAM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108585-A1 | BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | GAA 684/4885MGAM 2896/4885SI 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.