⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8277825 | 0.71 | PARP1 (0.55) | — | |
| SCHEMBL13041691 | 0.70 | ALDH1A1 (0.59) | — | |
| SCHEMBL12213872 | 0.69 | MAPT (0.68) | — | |
| SCHEMBL15767763 | 0.67 | NPC1 (0.41) | — | |
| SCHEMBL1038167 | 0.65 | FABP6 (0.63) | — | |
| SCHEMBL13947194 | 0.65 | ALDH1A1 (0.53) | — | |
| SCHEMBL111276 | 0.65 | RAB9A (0.66) | — | |
| SCHEMBL2745140 | 0.65 | GPR84 (0.48) | — | |
| SCHEMBL2745080 | 0.65 | GPR84 (0.48) | — | |
| SCHEMBL2744745 | 0.65 | NPC1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |
| US-20170165248-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2017-06-15 | — | — | US | disclosed |
| US-20170165248-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2017-06-15 | — | — | US | disclosed |
| US-9580409-B2 | Modulators of opioid receptors and methods of use thereof | SUNOVION PHARMACEUTICALS, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-9226921-B2 | Fused heterocyclic compounds as phosphodiesterases (PDES) inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-05 | — | — | US | disclosed |
| US-9226921-B2 | Fused heterocyclic compounds as phosphodiesterases (PDES) inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-01-05 | — | — | US | disclosed |
| US-20150079186-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-20150079186-A1 | SOLID DOSAGE FORM COMPRISING PROTON PUMP INHIBITOR AND SUSPENSION MADE THEREOF | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-8962688-B2 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG (CH) | 2015-02-24 | — | — | US | disclosed |
| US-8962688-B2 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG (CH) | 2015-02-24 | — | — | US | disclosed |
| US-20070276006-A1 | Method for the treatment of gastrointestinal disorders | SUCAMPO AG | 2007-11-29 | — | — | US | disclosed |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| WO-2007075381-A2 | PHARMACEUTICAL COMPOSITIONS OF ILAPRAZOLE | TAP PHARMACEUTICAL PRODUCTS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007064932-A2 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE | BAYER HEALTHCARE LLC. (US) | 2007-06-07 | — | — | WO | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20070053981-A1 | Solid composition comprising a proton pump inhibitor | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | US | disclosed |
| US-20070053981-A1 | Solid composition comprising a proton pump inhibitor | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | US | disclosed |
| US-7169793-B2 | Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof | DR. REDDY'S LABORATORIES LIMITED (IN) | 2007-01-30 | — | — | US | disclosed |