Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 16/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.77 |
| ▸ | RXRA | P19793 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548520 | 0.90 | PPARG (0.85) | PPARGPTGS1RXRA | |
| SCHEMBL4548581 | 0.88 | PPARG (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL4548513 | 0.88 | PPARG (0.78) | PPARGPTGS1RXRA | |
| SCHEMBL4548564 | 0.88 | PPARG (0.79) | PPARGPTGS1RXRA | |
| SCHEMBL4548565 | 0.88 | PPARG (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL2697270 | 0.87 | PPARG (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL12181897 | 0.87 | RXRA (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL4548522 | 0.87 | PPARG (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL2582996 | 0.87 | PPARG (1.00) | PPARGPTGS1RXRA | |
| SCHEMBL2582994 | 0.87 | PPARG (1.00) | PPARGPTGS1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168656-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168656-B2 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY | 2009-05-07 | — | — | US | disclosed |
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | VANDERBILT UNIVERSITY | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118290-A1 | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity | AANAT, FABP2, SI | PPARG 9/4885PTGS1 25/4885RXRA 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.