SCHEMBL4549387

SCHEMBL4549387

c1ccc(C2(c3ccccc3)c3cc(-c4cc5ccccc5c5ccccc45)ccc3-c3ccc(-c4cccc5c4oc4ccccc45)cc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.49
GGPS1 O95749 1/20 0.38
PRKDC P78527 7/20 0.38
PTGES2 Q9H7Z7 1/20 0.36
PIK3CD O00329 1/20 0.32
PIK3CB P42338 1/20 0.32
MAPK1 P28482 2/20 0.32
PRMT5 O14744 1/20 0.32
WDR77 Q9BQA1 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CASP1 P29466 1/20 0.32
HIF1A Q16665 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ATM Q13315 1/20 0.32
CYP11B1 P15538 1/20 0.32
KMT2A Q03164 1/20 0.31
CDC14B O60729 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20277499 0.92 ALOX5 (0.57) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549381 0.91 ALOX5 (0.51) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL18086161 0.89 ALOX5 (0.54) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549434 0.89 ALOX5 (0.43) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL25052981 0.86 ALOX5 (0.49) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549397 0.86 ALOX5 (0.51) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL18086151 0.86 ALOX5 (0.51) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL18325994 0.85 ALOX5 (0.41) ALOX5GGPS1PRKDCPTGES2KMT2A
SCHEMBL14554598 0.85 ALOX5 (0.46) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL24749353 0.84 ALOX5 (0.38) ALOX5GGPS1PRKDCPTGES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885GGPS1 1183/4885PRKDC 4132/4885
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885GGPS1 1183/4885PRKDC 4132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.