SCHEMBL4549381

SCHEMBL4549381

c1ccc2c(c1)-c1ccccc1C21c2cc(-c3cc4ccccc4c4ccccc34)ccc2-c2ccc(-c3cccc4c3oc3ccccc34)cc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.51
GGPS1 O95749 1/20 0.39
PRKDC P78527 6/20 0.39
PTGES2 Q9H7Z7 1/20 0.37
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 2/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CB P42338 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
HIF1A Q16665 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33
ATM Q13315 2/20 0.33
CYP11B1 P15538 1/20 0.33
AHR P35869 2/20 0.31
CYP2C19 P33261 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12996570 0.91 ALOX5 (0.59) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL17614164 0.91 ALOX5 (0.59) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549387 0.91 ALOX5 (0.49) ALOX5GGPS1PRKDCPTGES2ALDH1A1
SCHEMBL4549437 0.91 ALOX5 (0.46) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549397 0.88 ALOX5 (0.51) ALOX5GGPS1PRKDCPTGES2ALDH1A1
SCHEMBL20173010 0.88 ALOX5 (0.53) ALOX5GGPS1PRKDCPTGES2ALDH1A1
SCHEMBL18086164 0.88 ALOX5 (0.56) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL10057966 0.85 ALOX5 (0.53) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549434 0.85 ALOX5 (0.43) ALOX5GGPS1PRKDCPTGES2PIK3CD
SCHEMBL4549366 0.85 ALOX5 (0.60) ALOX5GGPS1PRKDCPTGES2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885GGPS1 1183/4885PRKDC 4132/4885
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885GGPS1 1183/4885PRKDC 4132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.