Phosphoric Acid

Phosphoric Acid

SCHEMBL455111

O=C1OCCN1c1ccccc1.O=P(O)(O)O

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 1/20 0.48
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
KDM1A O60341 5/20 0.42
MAOA P21397 4/20 0.42
MAOB P27338 4/20 0.42
RCOR1 Q9UKL0 4/20 0.42
HSD11B1 P28845 1/20 0.42
KDM1B Q8NB78 2/20 0.42
BCL2 P10415 2/20 0.41
BECN1 Q14457 1/20 0.41
NAAA Q02083 4/20 0.40
FAAH O00519 2/20 0.40
SLC9A3 P48764 1/20 0.39
KDM4E B2RXH2 2/20 0.39
F10 P00742 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297319 0.91 MEN1 (0.54) TNKSMEN1NPC1RAB9AKMT2A
SCHEMBL27645807 0.89 TNKS (0.52) TNKSMEN1NPC1RAB9AKMT2A
Boric Acid SCHEMBL27822670 0.88 TNKS (0.49) TNKSMEN1NPC1RAB9AKMT2A
SCHEMBL27365143 0.85 TNKS (0.47) TNKSMEN1NPC1RAB9AKMT2A
Piperazine SCHEMBL3193494 0.83 TNKS (0.51) TNKSMEN1NPC1RAB9AKMT2A
SCHEMBL991958 0.80 MEN1 (0.50) TNKSMEN1NPC1RAB9AKMT2A
Pyrrolidine SCHEMBL5240466 0.80 TNKS (0.49) TNKSMEN1NPC1RAB9AKMT2A
Propionamide SCHEMBL27921355 0.80 TNKS (0.43) TNKSMEN1NPC1RAB9AKMT2A
SCHEMBL6972215 0.79 TNKS (0.45) TNKSMEN1NPC1RAB9AKMT2A
Piperidine SCHEMBL3263324 0.79 TNKS (0.48) TNKSMEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012033952-A1 3 - PHENYL- 2 -OXO- 1, 3 -OXAZOLIDINES FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS, INC. (KY) 2012-03-15 WO disclosed