SCHEMBL4551176

SCHEMBL4551176

Cc1nn(C)c(F)c1C(=O)Nc1ccsc1CC[Si](C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HSD17B10 Q99714 2/20 0.36
USP2 O75604 1/20 0.36
ALOX15 P16050 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
ATM Q13315 1/20 0.32
MAPT P10636 1/20 0.32
POLB P06746 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3116588 0.86 CYP1A2 (0.35) HPGDMEN1KMT2AHSD17B10USP2
SCHEMBL3117713 0.86 MAPT (0.37) HPGDMEN1KMT2AHSD17B10USP2
SCHEMBL5577995 0.76 ABCC1 (0.37) HPGDMEN1KMT2AHSD17B10USP2
SCHEMBL3114153 0.75 CYP1A2 (0.35) HPGDMEN1KMT2AHSD17B10USP2
SCHEMBL12798725 0.75 ATM (0.38) ATM
SCHEMBL12798733 0.74 ATM (0.41) HPGDMEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL3108352 0.74 CYP1A2 (0.34) HPGDMEN1KMT2AHSD17B10USP2
SCHEMBL12798723 0.73 LMNA (0.52) GAAATMPOLB
SCHEMBL15132717 0.73 RAB9A (0.49) MEN1KMT2AL3MBTL1GAASMN1; SMN2
SCHEMBL13292700 0.73 PRNP (0.36) HPGDMEN1KMT2AHSD17B10USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7897780-B2 Method for controlling phytopathogenic fungi using silylated carboxamides BAYER CROPSCIENCE AG (DE) 2011-03-01 US disclosed
US-7897780-B2 Method for controlling phytopathogenic fungi using silylated carboxamides BAYER CROPSCIENCE AG (DE) 2011-03-01 US disclosed
EP-1727816-B1 MICROBICIDAL SILYLATED CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2009-12-30 EP disclosed
US-20070293455-A1 Silylated Carboxamides BAYER CROPSCIENCE AG (DE) 2007-12-20 US disclosed
US-20070293455-A1 Silylated Carboxamides BAYER CROPSCIENCE AG (DE) 2007-12-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070293455-A1 Silylated Carboxamides MRPL21, MRPS22, MRM1 HPGD 4447/4885MEN1 636/4885KMT2A 312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.