Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.46 |
| ▸ | RAF1 | P04049 | 7/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5601764 | 0.94 | BRAF (0.40) | BRAFRAF1 | |
| SCHEMBL4551383 | 0.87 | BRAF (0.54) | BRAFRAF1 | |
| SCHEMBL4410231 | 0.82 | BRAF (0.48) | BRAFRAF1 | |
| SCHEMBL4417865 | 0.81 | BRAF (0.47) | BRAFRAF1 | |
| SCHEMBL4408526 | 0.80 | RAF1 (0.57) | BRAFRAF1 | |
| SCHEMBL4552240 | 0.79 | RAF1 (0.50) | BRAFRAF1 | |
| SCHEMBL4565118 | 0.79 | RAF1 (0.56) | BRAFRAF1 | |
| SCHEMBL5603943 | 0.78 | RAF1 (0.45) | BRAFRAF1CNR2 | |
| SCHEMBL5604341 | 0.78 | MAPK14 (0.43) | BRAFRAF1 | |
| SCHEMBL4551892 | 0.78 | RAF1 (0.44) | BRAFRAF1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |