SCHEMBL4551401

SCHEMBL4551401

ONCC1Oc2ccccc2O1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.55
MTNR1A P48039 1/20 0.41
HPGD P15428 3/20 0.39
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
POLB P06746 1/20 0.37
LMNA P02545 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13940260 0.77 CA2 (0.55) CA2MTNR1AHPGDALDH1A1SMN1; SMN2
SCHEMBL4333283 0.73 CA2 (0.45) CA2MTNR1AHPGDALDH1A1SMN1; SMN2
SCHEMBL9695874 0.72 MTNR1A (0.65) CA2MTNR1AHPGDALDH1A1SMN1; SMN2
SCHEMBL407192 0.71 CA2 (1.00) CA2
SCHEMBL4973068 0.70 CA2 (0.47) CA2MTNR1APOLBHTT
SCHEMBL5320559 0.70 CA2 (0.47) CA2MTNR1AHPGDSMN1; SMN2NPC1
SCHEMBL6272291 0.70 CA2 (0.42) CA2MTNR1AHPGDALDH1A1SMN1; SMN2
SCHEMBL3072276 0.69 MAOA (0.46) CA2HPGDALDH1A1SMN1; SMN2POLB
SCHEMBL3763119 0.69 CA2 (0.45) CA2MTNR1AHPGDALDH1A1POLB
SCHEMBL9423459 0.69 CA2 (0.45) CA2MTNR1APOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2040698-A2 OXIME COMPOUNDS AND THE USE THEREOF SHIONOGI & CO., LTD. (JP) 2009-04-01 EP disclosed
WO-2008008398-A2 OXIME COMPOUNDS AND THE USE THEREOF SHIONOGI & CO., LTD. (JP) 2008-01-17 WO disclosed