Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 16/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552911 | 0.91 | CCR5 (0.50) | CCR5KCNH2 | |
| SCHEMBL4416636 | 0.81 | CCR5 (0.52) | CCR5KCNH2 | |
| SCHEMBL14185474 | 0.78 | CCR5 (0.64) | CCR5KCNH2 | |
| SCHEMBL4551472 | 0.78 | CCR5 (0.49) | CCR5KCNH2HSD11B1 | |
| SCHEMBL4552096 | 0.78 | CCR5 (0.56) | CCR5KCNH2 | |
| SCHEMBL14185345 | 0.78 | CCR5 (0.55) | CCR5KCNH2 | |
| SCHEMBL14185374 | 0.78 | CCR5 (0.53) | CCR5KCNH2 | |
| SCHEMBL3749999 | 0.77 | CCR5 (0.50) | CCR5KCNH2 | |
| SCHEMBL14185417 | 0.77 | CCR5 (0.59) | CCR5KCNH2 | |
| SCHEMBL14185344 | 0.77 | CCR5 (0.49) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2088860-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070758-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |