Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 11/20 | 0.46 |
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551605 | 0.91 | POLB (0.46) | MAPTKDM4EPOLBRAF1BRAF | |
| SCHEMBL4551777 | 0.90 | BRAF (0.51) | MAPTKDM4EPOLBRAF1BRAF | |
| SCHEMBL4408316 | 0.88 | MAPK14 (0.49) | RAF1BRAFTP53MAPK14SMN1; SMN2 | |
| SCHEMBL4407770 | 0.85 | MAPK14 (0.51) | RAF1BRAFMAPK14 | |
| SCHEMBL4409940 | 0.85 | RAF1 (0.53) | RAF1BRAFMAPK14 | |
| SCHEMBL4412693 | 0.85 | RAF1 (0.49) | RAF1BRAF | |
| SCHEMBL4418552 | 0.83 | MAPK14 (0.44) | MAPTRAF1BRAFTP53MAPK14 | |
| SCHEMBL4416214 | 0.82 | MAPK14 (0.43) | MAPTRAF1BRAFLMNATP53 | |
| SCHEMBL4541481 | 0.82 | RAB9A (0.47) | RAF1BRAFMAPK14NPC1RAB9A | |
| SCHEMBL4418487 | 0.82 | MAPK14 (0.48) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |