Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.51 |
| ▸ | RAF1 | P04049 | 8/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409940 | 0.94 | RAF1 (0.53) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL4541475 | 0.91 | RAF1 (0.56) | BRAFRAF1MAPK14 | |
| SCHEMBL14473104 | 0.90 | RAF1 (0.52) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL4551775 | 0.90 | MAPT (0.48) | BRAFRAF1MAPK14MAPTKDM4E | |
| SCHEMBL4551606 | 0.90 | MAPT (0.47) | BRAFRAF1MAPK14MAPTKDM4E | |
| SCHEMBL5603999 | 0.87 | MAPK14 (0.53) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL4551566 | 0.87 | BRAF (0.49) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL5593544 | 0.86 | RAF1 (0.59) | BRAFRAF1MAPK14 | |
| SCHEMBL4551494 | 0.85 | MAPK14 (0.51) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL4551976 | 0.85 | RAF1 (0.52) | BRAFRAF1MAPK14MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |