Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551631 | 0.89 | GRM4 (0.49) | GRM4NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5604346 | 0.88 | HTT (0.42) | NPC1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL5602271 | 0.87 | HTT (0.43) | SMN1; SMN2TSHRHTT | |
| SCHEMBL4407836 | 0.78 | NR1H4 (0.45) | KDM4EHTT | |
| SCHEMBL4414236 | 0.76 | NAMPT (0.43) | NPC1RAB9ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL5593328 | 0.76 | RXFP1 (0.43) | KDM4ETSHRHTT | |
| SCHEMBL5592971 | 0.75 | RXFP1 (0.42) | SMN1; SMN2KDM4ETSHRHTT | |
| SCHEMBL4417707 | 0.75 | CYP3A4 (0.43) | RAB9ASMN1; SMN2KDM4ETSHRHTT | |
| SCHEMBL5616375 | 0.74 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2KDM4ETSHR | |
| SCHEMBL5602261 | 0.74 | HTT (0.43) | TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |