Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551653 | 0.91 | DDR2 (0.55) | NR3C1PLAUDDR2NTRK1KDR | |
| SCHEMBL4551496 | 0.86 | MAPK14 (0.51) | PLAUKDRPDE4BMAPK14MAPK13 | |
| SCHEMBL5499408 | 0.83 | DDR2 (0.54) | NR3C1PLAUDDR2KDRHTR2A | |
| SCHEMBL4551754 | 0.82 | PLAU (0.46) | PLAUPDE4BMAPK14MAPK13MAPK12 | |
| SCHEMBL4552257 | 0.80 | PDE4B (0.44) | PLAUPDE4BMAPK14MAPTSMN1; SMN2 | |
| SCHEMBL4551615 | 0.79 | PDE4B (0.45) | PLAUPDE4BMAPK14MAPTSMN1; SMN2 | |
| SCHEMBL4409060 | 0.79 | MAPK14 (0.54) | PLAUPDE4BMAPK14MAPK13MAPK12 | |
| SCHEMBL4551322 | 0.78 | MAPK14 (0.61) | HTR2AMAPK14METMAPTSMN1; SMN2 | |
| SCHEMBL4551497 | 0.77 | MAPK14 (0.60) | PLAUKDRMAPK14MAPK13MAPK12 | |
| SCHEMBL4551330 | 0.77 | MAPK14 (0.60) | HTR2AMAPK14METMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |