Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551497 | 0.91 | MAPK14 (0.60) | MAPK14LCKMAPTMEN1KMT2A | |
| SCHEMBL4551652 | 0.86 | NR3C1 (0.53) | MAPK14MAPTPDE4BKDRPLAU | |
| SCHEMBL4409060 | 0.82 | MAPK14 (0.54) | MAPK14MAPTPDE4BMEN1KMT2A | |
| SCHEMBL4551754 | 0.81 | PLAU (0.46) | MAPK14PDE4BPLAUMAPK13MAPK12 | |
| SCHEMBL4418530 | 0.80 | MAPK14 (0.61) | MAPK14MAPTMEN1KMT2AMAPK13 | |
| SCHEMBL4417663 | 0.79 | MAPK14 (0.59) | MAPK14MAPTMEN1KMT2APLAU | |
| SCHEMBL4551322 | 0.79 | MAPK14 (0.61) | MAPK14MAPTL3MBTL1 | |
| SCHEMBL4552257 | 0.79 | PDE4B (0.44) | MAPK14MAPTPDE4BPLAUBRAF | |
| SCHEMBL4551330 | 0.79 | MAPK14 (0.60) | MAPK14MAPTL3MBTL1 | |
| SCHEMBL4551615 | 0.78 | PDE4B (0.45) | MAPK14MAPTPDE4BPLAUBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |