5-Nitroisatin

5-Nitroisatin

SCHEMBL455170

O=C1Nc2ccc([N+](=O)[O-])cc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CAPN9 O14815 1/20 1.00
CASP3 P42574 1/20 1.00
MEN1 O00255 1/20 0.69
KMT2A Q03164 1/20 0.69
CYP3A4 P08684 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
EGFR P00533 1/20 0.60
PTPRC P08575 1/20 0.56
S100A4 P26447 1/20 0.56
CA12 O43570 2/20 0.56
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
CA9 Q16790 2/20 0.56
PDGFRB P09619 1/20 0.55
JAK3 P52333 1/20 0.55
GSK3B P49841 3/20 0.53
NOX4 Q9NPH5 1/20 0.53
ALDH1A1 P00352 1/20 0.53
TGM2 P21980 4/20 0.53
CES1 P23141 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-Nitroisatin SCHEMBL29497975 1.00 CAPN9 (1.00) CAPN9CASP3MEN1KMT2ACYP3A4
5-Nitroisatin SCHEMBL28279171 0.98 CAPN9 (0.97) CAPN9CASP3MEN1KMT2ACYP3A4
5-Nitroisatin SCHEMBL27856567 0.92 CAPN9 (0.85) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL31376381 0.86 CASP3 (0.75) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL2521332 0.86 CASP3 (0.75) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL23385135 0.83 TGM2 (0.71) CAPN9CASP3MEN1KMT2AEGFR
SCHEMBL13083518 0.83 CAPN9 (0.71) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL13080515 0.83 CAPN9 (0.71) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL6298018 0.81 KMT2A (1.00) CAPN9CASP3MEN1KMT2ACYP3A4
SCHEMBL9388949 0.79 CAPN9 (0.65) CAPN9CASP3MEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 459 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119684105-A N-phenyl isatin-mediated ketone-carboxylic acid conversion reaction method 贵州医科大学 2025-03-25 CN claimed
WO-2024137720-A2 PIPERIDINIUM-CONTAINING ANION EXCHANGE POLYMERS VERSOGEN, INC. (US) 2024-06-27 WO claimed
CN-117586485-A Sulfonated hydrocarbon polymer containing protecting group, synthesis method and application thereof in low-temperature proton exchange membrane fuel cell 中国科学院山西煤炭化学研究所 2024-02-23 CN claimed
WO-2023027630-A9 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-07-27 WO claimed
CN-114950159-B Preparation method of aromatic polymer separation membrane based on super acid catalysis 南京工业大学 2023-06-06 CN claimed
WO-2023027630-A2 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-03-02 WO claimed
CN-114950159-A Preparation method of aromatic polymer separation membrane based on super-acid catalysis preparation 南京工业大学 2022-08-30 CN claimed
CN-112898290-B Isoxazole formamido-4 (3H) -quinazolinone derivative and synthesis method and application thereof 中南大学 2022-08-05 CN claimed
CN-112898290-A Isoxazole formamido-4 (3H) -quinazolinone derivative and synthesis method and application thereof 中南大学 2021-06-04 CN claimed
CN-110734391-A 2, 3-diketone indole compound and preparation method and application thereof 山东大学 2020-01-31 CN claimed
US-6635090-B1 Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL, S.A. (FR) 2003-10-21 US claimed
EP-0999203-B1 Novel developer in oxidative hair dyeing CLAIROL INC (US) 2003-02-26 EP claimed
US-6458168-B1 Hair dyeing method using an aliphatic cationic amine and compound chosen from an aldehyde, a ketone, a quinone, a di-imino-isoindoline, and a 3-aminoisoindolone derivative L'OREAL S.A. (FR) 2002-10-01 US claimed
EP-1006104-B1 P-aminophenol substitute and its use in oxidation dye formulations CLAIROL INC (US) 2002-09-25 EP claimed
US-6451067-B1 HAIR DYE MIXTURE L'OREAL S.A. (FR) 2002-09-17 US claimed
US-6114540-A COMBINATORIAL LIBRARIES ARQULE, INC. (US) 2000-09-05 US claimed
EP-1006104-A1 P-aminophenol substitute and its use in oxidation dye formulations Bristol-Myers Squibb Company (US) 2000-06-07 EP claimed
EP-0999203-A1 Novel developer in oxidative hair dyeing Bristol-Myers Squibb Company (US) 2000-05-10 EP claimed
US-5980584-A NONTOXIC; REPLACEMENT FOR P-AMINOPHENOL IN OXIDATIVE HAIR DYE SYSTEMS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US claimed
US-4094687-A A DIIMINOPIPERAZINE-ALDEHYDE CONDENSATION PRODUCT AND CYCLIC POLYKETO COMPOUND GRAPHIC CONTROLS CORPORATION 1978-06-13 US claimed