Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | RAF1 | P04049 | 9/20 | 0.43 |
| ▸ | BRAF | P15056 | 9/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603194 | 0.91 | RAF1 (0.43) | MAPK14RAF1BRAFPLAUPOLB | |
| SCHEMBL4552281 | 0.89 | RAF1 (0.45) | MAPK14RAF1BRAFPLAUGPR183 | |
| SCHEMBL4551704 | 0.89 | MAPK14 (0.57) | MAPK14RAF1BRAF | |
| SCHEMBL4541474 | 0.89 | RAF1 (0.42) | MAPK14RAF1BRAFPLAU | |
| SCHEMBL4541525 | 0.87 | ACKR3 (0.44) | MAPK14RAF1BRAFPLAUGPR183 | |
| SCHEMBL4551892 | 0.87 | RAF1 (0.44) | MAPK14RAF1BRAFPLAUGPR183 | |
| SCHEMBL5604081 | 0.86 | RAF1 (0.42) | MAPK14RAF1BRAFPLAUPOLB | |
| SCHEMBL5603996 | 0.85 | NAMPT (0.45) | MAPK14RAF1BRAF | |
| SCHEMBL5602744 | 0.85 | RAB9A (0.43) | MAPK14RAF1BRAF | |
| SCHEMBL4551381 | 0.85 | RAB9A (0.53) | RAF1BRAFPLAUPOLBGPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |