SCHEMBL4551706

SCHEMBL4551706

Nc1cccc(O)c1N.[C]F

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.52
TSHR P16473 3/20 0.52
CASP7 P55210 2/20 0.45
G6PD P11413 1/20 0.45
CASP6 P55212 1/20 0.45
CD44 P16070 1/20 0.42
TDP1 Q9NUW8 4/20 0.39
ALDH1A1 P00352 3/20 0.39
HPGD P15428 3/20 0.39
HSD17B10 Q99714 3/20 0.39
EGFR P00533 2/20 0.39
CA2 P00918 2/20 0.39
LMNA P02545 2/20 0.39
FYN P06241 2/20 0.39
MMP9 P14780 2/20 0.39
RECQL P46063 2/20 0.39
MMP2 P08253 2/20 0.39
ADAMTS4 O75173 1/20 0.39
CA1 P00915 1/20 0.39
MMP8 P22894 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL190980 0.92
SCHEMBL29623283 0.92
SCHEMBL31384129 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
Hydrochloric Acid SCHEMBL3000038 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
SCHEMBL27860891 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
Methane SCHEMBL27498461 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
Hydrochloric Acid SCHEMBL7691097 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
SCHEMBL15541144 0.90 ALOX15 (0.57) ALOX15TSHRCASP7G6PDCASP6
Formaldehyde SCHEMBL28382208 0.85 ALOX15 (0.52) ALOX15TSHRCASP7G6PDCASP6
SCHEMBL4083700 0.83 ALOX15 (0.50) ALOX15TSHRCASP7G6PDCASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1587784-B1 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2014-10-15 EP disclosed
US-7521510-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC (US) 2009-04-21 US disclosed
EP-1587784-A4 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE TWEED INC (US) 2008-10-29 EP disclosed
US-7247749-B2 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-07-24 US disclosed
US-20070027260-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2007-02-01 US disclosed
EP-1587784-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2005-10-26 EP disclosed
US-20050020859-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. (US) 2005-01-27 US disclosed
WO-2005000917-A1 BISAMINOPEHNYL-BASED CURATIVES CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS. GREENE, TWEED OF DELAWARE, INC. (US) 2005-01-06 WO disclosed
US-20040214956-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions GREENE, TWEED OF DELAWARE, INC. 2004-10-28 US disclosed
WO-2004069900-A2 BISAMINOPHENYL-BASED CURATIVES AND AMIDINE-BASED CURATIVES AND CURE ACCELERATORS FOR PERFLUOROELASTOMERIC COMPOSITIONS GREENE, TWEED OF DELAWARE, INC. (US) 2004-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020859-A1 Bisaminophenyl-based curatives and amidine-based curatives and cure accelerators for perfluoroelastomeric compositions PFAS, FPGS, ALKBH2 ALOX15 2070/4885TSHR 1694/4885CASP7 30/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.