SCHEMBL4551989

SCHEMBL4551989

CC(=O)c1ccccc1C[C@H](N)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 4/20 0.60
NOS1 P29475 4/20 0.60
NOS2 P35228 4/20 0.60
SLC7A5 Q01650 7/20 0.59
PKM P14618 2/20 0.59
PTGS1 P23219 2/20 0.59
ALPI P09923 1/20 0.59
XIAP P98170 1/20 0.59
MAPT P10636 3/20 0.49
KDM4E B2RXH2 3/20 0.49
HIF1A Q16665 3/20 0.49
MEN1 O00255 2/20 0.49
LMNA P02545 2/20 0.49
BLM P54132 2/20 0.49
PMP22 Q01453 2/20 0.49
KMT2A Q03164 2/20 0.49
MPO P05164 1/20 0.49
TSHR P16473 1/20 0.49
RECQL P46063 3/20 0.48
ALDH1A1 P00352 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4792772 1.00 NOS3 (0.60) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL29475631 0.86 PKM (0.58) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL31370153 0.86 PKM (0.58) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL1527682 0.86 PKM (0.58) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL1527683 0.86 PKM (0.58) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL30440587 0.84 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL29637605 0.84 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL668476 0.84 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL42486 0.84 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM
SCHEMBL42487 0.84 NOS3 (0.59) NOS3NOS1NOS2SLC7A5PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114207129-A Agents and methods for replication, transcription and translation in semi-synthetic organisms 斯克利普斯研究所 2022-03-18 CN disclosed
EP-1613735-A4 EXPANDING THE EUKARYOTIC GENETIC CODE SCRIPPS RESEARCH INST (US) 2009-01-28 EP disclosed
EP-1718664-A4 MODIFIED HUMAN FOUR HELICAL BUNDLE POLYPEPTIDES AND THEIR USES AMBRX INC (US) 2008-08-13 EP disclosed
EP-1558747-A4 GLYCOPROTEIN SYNTHESIS SCRIPPS RESEARCH INST (US) 2007-07-18 EP disclosed
EP-1578949-A4 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS SCRIPPS RESEARCH INST (US) 2006-12-20 EP disclosed
EP-1718664-A2 MODIFIED HUMAN FOUR HELICAL BUNDLE POLYPEPTIDES AND THEIR USES Ambrx, Inc. (US) 2006-11-08 EP disclosed
EP-1613735-A2 EXPANDING THE EUKARYOTIC GENETIC CODE The Scripps Research Institute (US) 2006-01-11 EP disclosed
EP-1578949-A3 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS The Scripps Research Institute (US) 2005-11-10 EP disclosed
EP-1578949-A2 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS The Scripps Research Institute (US) 2005-09-28 EP disclosed
WO-2005074650-A2 MODIFIED HUMAN FOUR HELICAL BUNDLE POLYPEPTIDES AND THEIR USES AMBRX, INC. (US) 2005-08-18 WO disclosed
EP-1558747-A2 GLYCOPROTEIN SYNTHESIS The Scripps Research Institute (US) 2005-08-03 EP disclosed
WO-2004094593-A2 EXPANDING THE EUKARYOTIC GENETIC CODE THE SCRIPPS RESEARCH INSTITUTE (US) 2004-11-04 WO disclosed
WO-2004035743-A2 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS THE SCRIPPS RESEARCH INSTITUTE (US) 2004-04-29 WO disclosed
WO-2004035605-A2 GLYCOPROTEIN SYNTHESIS THE SCRIPPS RESEARCH INSTITUTE (US) 2004-04-29 WO disclosed